今年美国生物制药领域最火热的两个新靶点药无疑是GLP-1激动剂和beta-amyloid拮抗剂,后者用于治疗AD(阿尔兹海默症),即老年痴呆症的一种。今年Biogen的Leqembi获得了FDA的批准。Leqembi虽然不能治愈或逆转AD,但是可以将该疾病进展缓解几个月。Biogen CEO Chris Viehbacher在接受STAT采访对于Leqembi和AD药物开发做了个比喻特别好,他说:“People have been throwing things at castle walls for decades, trying to make any dent, this is first time we put a chunk in the wall.” 这让我想起了HIV治愈研究,过去十年其实HIV领域就是throwing things at castle walls try to make a …