Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells

CONCLUSION: Our findings show that combined inhibition of RNR and WEE1 was effective against Ewing’s sarcoma in vitro. They thus provide a rationale for the evaluation of the potential of combined targeting of RNR and WEE1 in Ewing’s sarcoma in …