Five-gene expression signature associated with acquired FOLFIRI resistance and survival in metastatic colorectal cancer

FOLFIRI, a combination of folinic acid, 5-Fluorouracil, and Irinotecan, is one of the recommended first-line chemotherapeutic treatments for metastatic colorectal cancer (mCRC). Unfortunately, acquired FOLFIRI resistance represents a common obstacle in the treatment of mCRC patients. Thus, we aimed to identify mechanisms, gene alterations and gene expression signatures contributing to acquired FOLFIRI resistance by mimicking this problem in a cell culture model and subsequent translation …