The capability of cells to sense and respond to endogenous electrical fields plays a crucial role in processes like nerve regeneration, wound healing, and development. In vitro, many cell types respond to electrical fields by migrating along the corresponding electrical field vectors. This process is known as galvano- or electrotaxis. Here we report on the combined impact of micro-confinements and direct current electrical fields (dcEFs) on the motility of MDA-MB-231 human breast cancer …