Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface

Controlled development of cellular intestinal immunity in the face of dynamic microbiota emergence constitutes a major challenge in very early life, and a bottleneck for sustained growth and well-being. Early-onset inflammatory bowel disease (IBD) represents an extreme disturbance of intestinal immunity. It is a hallmark, and often the first manifestation of chronic granulomatous disease (CGD), caused by inborn defects in the NADPH oxidase NOX2 and thus the failure to produce reactive …