The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance of DNMT3A-destabilizing mutations (DNMT3A^(INS)) in AML, we here investigate the common characteristics of DNMT3A^(INS) AML methylomes through computational analyses. We present that methylomes of DNMT3A^(INS) AMLs are considerably different from those …