CONCLUSION: This data suggests that the amygdala is a robust region for detecting early tau aggregation by MK6240 PET and that a rise in plasma pTau217 is associated with early formation of NFT rather than a direct physiological response to brain Aβ plaques prior to NFT formation. Figure 1 legend: Modeling of ^(18)F-MK6240 quantification and pTau217 as a function of Centiloid. Biomarker values Z-scored using the results from Aβ- cognitively unimpaired to define the normal range for …