Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

CONCLUSIONS: Contact to silicone oils induces a major loss of functionality of bevacizumab and trastuzumab. This limits clinical use during silicone oil tamponade. The beneficial effect of adding polysorbate suggests that loss of solubilizer is a likely cause of aggregation. Hydrogels, alternatives for vitreous body replacement, do not impair antibody …