We provide an overview of the isotopic signatures of presolar supernova grains, specifically focusing on ^(44)Ti-containing grains with robustly inferred supernova origins and their implications for nucleosynthesis and mixing mechanisms in supernovae. Recent technique advancements have enabled the differentiation between radiogenic (from ^(44)Ti decay) and nonradiogenic ^(44)Ca excesses in presolar grains, made possible by enhanced spatial resolution of Ca-Ti isotope analyses with the …