In patients with prior CABG requiring subsequent PCI there is uncertainty whether bypass grafts or native coronary arteries should be targeted. We analysed data from 2,764 patients with prior CABG in the Melbourne Interventional Group registry (2005-2018), divided into two groups: those undergoing PCI to a native vessel (n=1,928) and those with PCI to a graft vessel (n=836).Patients with a graft vessel PCI were older, had more high-risk clinical characteristics (prior MI, heart failure, …