ETx-22: a novel nectin-4-directed antibody drug conjugate, demonstrates safety and potent antitumor activity in low nectin-4 expressing tumors

Nectin-4 is a cell-adhesion molecule expressed at various levels in many solid tumors, including urothelial cancer. As means to reduce on-target skin toxicity observed with enfortumab vedotin, an anti-nectin-4-MMAE ADC approved for patients with advanced urothelial cancer, 15A7.5, an anti-nectin-4 monoclonal antibody that exhibited differential nectin-4 binding between tumor and primary keratinocytes, was selected for the development of ETx-22. Exatecan, a topoisomerase I inhibitor, was …