Peripheral T-cell lymphomas (PTCLs) encompass a heterogeneous group of post-thymic T-cell lymphomas with more than 30 distinct subtypes associated with varied clinicopathological features. Unfortunately, the overall survival of the major PTCL subtypes is dismal and has not improved for decades, thus there is an urgent unmet clinical need to improve diagnosis, therapies, and clinical outcomes. The diagnosis is often challenging requiring a combinatorial evaluation of clinical, morphologic, …