CONCLUSIONS: In this proof-of-concept study, we show that pancreatic metastases of ccRCC present with unique immunological features including a low intratumoral density of CD8^(+) and FOXP3^(+) lymphocytes. The low counts of CD8^(+) and FOXP3^(+) lymphocytes may reflect less aggressive features of ccRCC with pancreatic metastasis that may result in a more favorable patient …