Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

CONCLUSIONS: Our findings suggest that loss of myofilament proteins, particularly reduced cTnC protein levels, causes diminished cytosolic Ca^(2+) buffering in persAF, thereby potentiating the occurrence of spontaneous Ca^(2+) release events and AF susceptibility. Strategies targeting intracellular buffering may represent a promising therapeutic lead in AF …