Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell (APC). As a consequence of the T cell receptor (TCR) interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction, the immunological synapse, forms and is accompanied by changes in the spatiotemporal patterning and function of intracellular signaling …