BACKGROUND AND OBJECTIVES: “Successful aging” as defined in Rowe & Kahn’s model aims to include the major domains of aging under a single overarching concept. From here the question arises how “successful aging” itself can be implemented as an endpoint in clinical research in a way that it is compliant to methodological regulatory framework and recommendations as formulated, for example, by the FDA. This article discusses from an applied perspective approaches and examples of how …