The success of hematopoietic transplant for hemoglobinopathies and hematological malignancies has been accompanied by the new challenge of how to identify, risk stratify and treat iron overload/toxicity pre- and post-transplantation. Substantial progress has been made in our understanding of iron metabolism and pathophysiology of iron overload, making us aware that not only the total amount of iron in the body is important but also the effect of toxic iron species and duration of exposure …