Targeted modulation of gene expression through receptor-specific delivery of small interfering RNA peptide conjugates

Small interfering RNA (siRNA) has emerged as a valuable tool to address RNA interference (RNAi) to modulate gene expression also in therapy. However, challenges such as inefficient cell targeting and rapid degradation in biological systems have limited its success. To address these issues, the development of a receptor-specific shuttle system represents a promising solution. [F⁷,P^(34)]-NPY analogues were modified by solid-phase peptide synthesis, enabling non-covalent conjugation with …