Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4^(-/-) mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal cavity of St3gal4^(-/-) mice. Ex vivo flow chamber assays uncovered reduced adhesion of St3gal4^(-/-) compared to wild type eosinophils. Using flow cytometry, …