CONCLUSIONS: S2814 phosphoresistance of RyR2 prevents the CaMKII-dependent SR Ca^(2+) leak induction but does not prevent the cardiomyopathic phenotype caused by enhanced CaMKIIδC activity. Our data indicate that additional mechanisms-independent of SR Ca^(2+) leak-are critical for the maladaptive effects of chronically increased CaMKIIδC activity with respect to heart …