3-year invasive disease-free survival with chemotherapy de-escalation using an ¹⁸F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial

BACKGROUND: PHERGain was designed to assess the feasibility, safety, and efficacy of a chemotherapy-free treatment based on a dual human epidermal growth factor receptor 2 (HER2) blockade with trastuzumab and pertuzumab in patients with HER2-positive early breast cancer (EBC). It used an ^(18)fluorine-fluorodeoxyglucose-PET-based, pathological complete response (pCR)-adapted …