Arterial and venous thromboses are classically considered distinct disease states, with arterial thrombosis mediated predominantly by platelets and, therefore, treated with antiplatelet therapy, and venous thrombosis mediated by the plasmatic coagulation system and, therefore, treated with anticoagulation. However, co-occurrence of arterial and venous events is common, and there is increasing evidence of shared risk factors and pathophysiologic overlap. This presents a management challenge: …