Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism

Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (T(reg)) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we show that the VAT harbors two distinct T(reg) cell populations: prototypical serum stimulation 2-positive (ST2^(+)) T(reg) cells that are enriched in males and a previously uncharacterized population of C-X-C motif chemokine receptor 3-positive (CXCR3^(+)) T(reg) cells that …