An ICIE16-bioactive glass (BG) composition (in mol%: 49.5 SiO(2), 6.6 Na(2)O, 36.3 CaO, 1.1 P(2)O(5), and 6.6 K(2)O) has demonstrated excellent in vitro cytocompatibility when cultured with human bone marrow-derived mesenchymal stromal cells (BMSCs). However, its impact on the development of an osseous extracellular matrix (ECM) is limited. Since zinc (Zn) is known to enhance ECM formation and maturation, two ICIE16-BG-based Zn-supplemented BG compositions, namely 1.5 Zn-BG and 3Zn-BG (in …