Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity

There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ(42)) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Aβ(42), which is increased from adipose tissue of male mice with obesity and is associated with higher plasma Aβ(42). Increasing circulating Aβ(42) levels in male mice without obesity has no effect on systemic glucose homeostasis but has …