Follicular lymphoma (FL) is a generally incurable malignancy that originates from developmentally blocked germinal center (GC) B cells residing, primarily, within lymph nodes (LNs). During the long natural history of FL, malignant B cells often disseminate to multiple LNs and can affect virtually any organ. Non-malignant LNs are highly organized structures distributed throughout the body where they perform functions critical for host defense. In FL, the malignant B cells “re-educate” …