Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL

Distinct diagnostic entities within BCR::ABL1-positive ALL are currently defined (ICC): ‘lymphoid-only’, with BCR::ABL1 observed exclusively in lymphatic precursors versus ‘multilineage’, where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of n=327 BCR::ABL1-positive ALL patients (age: 2 years - 84 years, median: 46) and identified two main gene expression clusters reproducible across four independent patient cohorts. FISH analysis of …