Type 1 VWD classification revisited - novel insights from combined analysis of the LoVIC and WiN studies

There is significant ongoing debate regarding type 1 VWD defintion. Previous guidelines recommended patients with VWF levels < 30 IU/dL be diagnosed type 1 VWD, whereas patients with significant bleeding and VWF levels 30-50 IU/dL be diagnosed with Low VWF. To elucidate the relationship between type 1 VWD and Low VWF in the context of age-induced increases in VWF levels, we combined datasets from two national cohort studies - 162 patients with Low VWF from the Low VWF in Ireland Cohort …