Malignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pH(i)). In this prospective study, pH(i) values in gliomas were quantified using high-resolution phosphorous 31 (^(31)P) spectroscopic MRI at 7.0 T and were used to correlate pH(i) alterations with histopathologic findings. A total of 12 participants (mean age, 58 years ± 18 [SD]; seven male, five female) with histopathologically …