Follicular lymphoma (FL) is an indolent yet incurable germinal center B-cell lymphoma retaining a characteristic follicular architecture. FL tumor B cells are highly dependent on direct and indirect interactions with a specific and complex tumor microenvironment (TME). Great progress has been recently made in describing the heterogeneity and dynamics of FL-TME and in depicting how tumor clonal and functional heterogeneity rely on the integration of TME-related signals. Specifically, FL-TME …