miR-222 inhibits pathological cardiac hypertrophyand heart failure

CONCLUSIONS: While miR-222 is necessary for physiological cardiac growth, it inhibits cardiac growth in response to pressure overload and reduces adverse remodeling and cardiac dysfunction. These findings support the model that physiological and pathological hypertrophy are fundamentally different. Further, they suggest miR-222 may hold promise as a therapeutic target in pathological cardiac hypertrophy and heart …