Decline in Left Ventricular Early Systolic Function with Worsening Kidney Function in Children with CKD: Insights from the 4C and HOT-KID Studies

CONCLUSIONS: Children with CKD exhibit a marked and progressive decline in EF1 with falling eGFR. This suggests that EF1 is a more sensitive marker of LV dysfunction when compared to other structural or functional measures and early LV systolic function a key feature in the pathophysiology of cardiac dysfunction in …