Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

State-of-the-art response assessment of central nervous system lymphoma (CNSL) by magnetic resonance imaging (MRI) is challenging and an insufficient predictor of treatment outcomes. Accordingly, the development of novel risk stratification strategies in CNSL is a high unmet medical need. We applied ultrasensitive circulating tumor (ct)DNA sequencing to 146 plasma and cerebrospinal fluid (CSF) samples from 67 patients, aiming to develop an entirely noninvasive dynamic risk model …