Targeted magnetic resonance imaging (tMRI) of small changes in the T₁ and spatial properties of normal or near normal appearing white and gray matter in disease of the brain using divided subtracted inversion recovery (dSIR) and divided reverse subtracted inversion recovery (drSIR) sequences

This review describes targeted magnetic resonance imaging (tMRI) of small changes in the T(1) and the spatial properties of normal or near normal appearing white or gray matter in disease of the brain. It employs divided subtracted inversion recovery (dSIR) and divided reverse subtracted inversion recovery (drSIR) sequences to increase the contrast produced by small changes in T(1) by up to 15 times compared to conventional T(1)-weighted inversion recovery (IR) sequences such as …