Short bowel syndrome (SBS) following extensive intestinal resection is often characterized by impaired absorption of orally administered drugs, including tyrosine kinase inhibitors (TKI). We report the case of a patient with EGFR-mutated non-small cell lung carcinoma treated with 80 mg/d of the TKI osimertinib who achieved partial response of the tumor, but was subsequently subjected to a double-barreled jejunostomy due to ileus. Due to the development of SBS after the bypass surgery, …