Across all settings, adult females self-report more drug allergies than adult males. Although there is epidemiological evidence of increased drug allergy labeling in post-pubertal females, the evidence base for female sex as a risk factor for true immune-mediated drug hypersensitivity reactions (DHR), particularly in fatal drug-induced anaphylaxis, is low. Focusing on the known immunological mechanisms described in immediate and delayed DHR, layered on known hormonal and genetic sex …