CONCLUSIONS: Nocturnal hypoxemia was related to brain AΞ² burden in this sample of OSA participants. AΞ² burden and hypoxemia had differential impacts on cognition. This study reveals aspects of sleep disturbance in OSA that are most strongly associated with brain AΞ² burden and poor cognition, which are markers of early Alzheimerβs disease. These findings add weight to the possibility that hypoxemia may be causally related to the development of dementia; however, whether they may be a β¦