Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis

CONCLUSION: The results highlight the importance of IL-1α on the cell surface of circulating leucocytes for the development of atherosclerosis. PCSK9-Il1a^(-/-) mice, but not PCSK9-Nlrp3^(-/-) or PCSK9-Il1b^(-/-) mice, are protected from atherosclerosis after induction of hypercholesterolemia independent of circulating cytokines. Myristoylation and translocation of IL-1α to the cell surface in myeloid cells facilitates leukocyte adhesion and contributes to the development of …