Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant adult-onset disorder caused by point mutations in the transthyretin (TTR) gene encoding TTR, i.e., prealbumin. ATTRv survival ranges from 3 to 10 years, and peripheral nervous system and heart are usually the two main tissues affected, although central nervous system and eye may also be involved. As liver is the main TTR protein secretor organ, it has been the main target of treatments developed these last years, …