BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

In this retrospective study, BRAFmutation status did not correlate with disease extent or (event-free) survival in 156 adults with LCH. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers - which may be clonally …