<u>P</u>enumbral <u>R</u>escue by Normobaric <u>O</u>=<u>O</u> Administration in Patients with Ischemic Stroke and Target Mismatch Pro<u>F</u>ile (PROOF): Study Protocol of a Phase IIb Trial

RATIONALE: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization …