Implementing A Byte Pair Encoding (BPE) Tokenizer From Scratch

2025-01-17

This is a standalone notebook implementing the popular byte pair encoding (BPE) tokenization algorithm, which is used in models like GPT-2 to GPT-4, Llama 3, etc., from scratch for educational …

deepin 25 preview DDE 移植简要指南

2025-01-16

MulitDeepsurv: survival analysis of gastric cancer based on deep learning multimodal fusion models

2025-01-16

Gastric cancer is a leading cause of cancer-related deaths globally. As mortality rates continue to rise, predicting cancer survival using multimodal data-including histopathological images, genomic data, and clinical information-has become increasingly crucial. However, extracting effective predictive features from this complex data has posed challenges for survival analysis due to the high dimensionality and heterogeneity of histopathology images and genomic data. Furthermore, existing …

MulitDeepsurv: survival analysis of gastric cancer based on deep learning multimodal fusion models

2025-01-16

Gastric cancer is a leading cause of cancer-related deaths globally. As mortality rates continue to rise, predicting cancer survival using multimodal data-including histopathological images, genomic data, and clinical information-has become increasingly crucial. However, extracting effective predictive features from this complex data has posed challenges for survival analysis due to the high dimensionality and heterogeneity of histopathology images and genomic data. Furthermore, existing …

Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with <em>NPM1</em>-mutated AML

2025-01-16

This study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with NPM1-mutated (NPM1 ^(mut)) AML. Targeted DNA sequencing of 263 genes was performed in 568 NPM1 ^(mut) AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were DNMT3A (49.8%), FLT3-TKD (25.9%), PTPN11 (24.8%), NRAS (22.7%), TET2 (21.7%), IDH2 (21.3%), …

Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with <em>NPM1</em>-mutated AML

2025-01-16

This study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with NPM1-mutated (NPM1 ^(mut)) AML. Targeted DNA sequencing of 263 genes was performed in 568 NPM1 ^(mut) AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were DNMT3A (49.8%), FLT3-TKD (25.9%), PTPN11 (24.8%), NRAS (22.7%), TET2 (21.7%), IDH2 (21.3%), …

Editorial: Regulatory problems and disorders in early childhood: aetiology, contextual factors, developmental outcomes and pathways, and treatment options

2025-01-16

Editorial: Regulatory problems and disorders in early childhood: aetiology, contextual factors, developmental outcomes and pathways, and treatment options

2025-01-16

Early childhood psychopathology and parental mental health during the COVID-19 pandemic: the effects of pandemic restrictions on 0- to 3-year-olds

2025-01-16

INTRODUCTION: The COVID-19 pandemic placed many restrictions on families and affected the mental health of parents and children. The present study examines how the restrictions imposed during the pandemic and parental mental health affect early childhood …

Early childhood psychopathology and parental mental health during the COVID-19 pandemic: the effects of pandemic restrictions on 0- to 3-year-olds

2025-01-16

INTRODUCTION: The COVID-19 pandemic placed many restrictions on families and affected the mental health of parents and children. The present study examines how the restrictions imposed during the pandemic and parental mental health affect early childhood …

Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large-Scaled Registry

2025-01-16

CONCLUSION: Although almost two thirds of patients hospitalized with HFmrEF were male, sex was no predictor for the risk of all-cause mortality at 30 months. However, female sex was associated with a higher risk of HF-related …

Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large-Scaled Registry

2025-01-16

CONCLUSION: Although almost two thirds of patients hospitalized with HFmrEF were male, sex was no predictor for the risk of all-cause mortality at 30 months. However, female sex was associated with a higher risk of HF-related …

Trifunctional lipid derivatives: PE's mitochondrial interactome

2025-01-16

Phosphatidylethanolamine (PE) is a ubiquitous lipid species in higher eukaryotes. Here, we synthesized a multifunctionalized PE derivative (1) designed to identify PE-binding proteins in intact cells through photo-crosslinking and subsequent isolation and proteomic analysis of the PE-protein conjugates. We show that the tool is also useful for tracking PE translocation to mitochondria after uncaging. A trifunctional phosphatidic acid derivative was rapidly metabolized and is of more limited …

Trifunctional lipid derivatives: PE's mitochondrial interactome

2025-01-16

Phosphatidylethanolamine (PE) is a ubiquitous lipid species in higher eukaryotes. Here, we synthesized a multifunctionalized PE derivative (1) designed to identify PE-binding proteins in intact cells through photo-crosslinking and subsequent isolation and proteomic analysis of the PE-protein conjugates. We show that the tool is also useful for tracking PE translocation to mitochondria after uncaging. A trifunctional phosphatidic acid derivative was rapidly metabolized and is of more limited …

Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression

2025-01-16

Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), and psychosocial stress was induced with the imaging stress paradigm ScanSTRESS. …

Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression

2025-01-16

Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), and psychosocial stress was induced with the imaging stress paradigm ScanSTRESS. …

Postoperative pancreatic fistula risk assessment using digital pathology based analyses at the parenchymal resection margin of the pancreas - Results from the randomized multicenter RECOPANC trial

2025-01-16

CONCLUSION: The present study is the first correlating AI-assisted quantified pancreatic tissue composition and POPF within a multicentric …

Ralph Nader, Consumer Crusader (Throwback)

2025-01-16

Whether it’s pesticides in your cereal or the door plug flying off your airplane, consumers today have plenty of reasons to feel like corporations might not have their best interests at heart. At a moment when the number of product recalls is high and trust in the government is low, we’re going to revisit a time when a generation of people felt empowered to demand accountability from both companies and elected leaders — and got results. Today on the show, the story of the U.S. consumer movement and its controversial leader: the once famous, now infamous Ralph Nader.To access bonus …